Projects & Participants for OLS-9 Catalyst

Andrew West (CC BY-NC-SA 2.0)

Participants join this program with a project that they either are already working on or want to develop during this program.

For this round of the Openseeds program, we are happy to have 27 participants with 10 projects.

Projects

Community Building in Biomedical Data Science in Sudan

By: Faisal Fadlelmola, Alyaa Elbadawi, Nihad Alsayed

Mentored by: Laurah Ondari

Keywords: Biomedical Data Science

This project aims to build and strengthen a biomedical data science community in Sudan through educational workshops, networking events, and collaborative projects. We will create a platform for data science professionals and enthusiasts to connect, share knowledge, and advance their skills.

Building a Community of a Critical mass of Bioinformaticians in Nigeria: Leveraging Open Science Principles

By: Seun Olufemi, Emmanuel Adamolekun, Ayomide Akinlotan

Mentored by: Malvika Sharan, Tajuddeen Gwadabe

Keywords: Community building, Open Science

This project aims to build a critical mass of bioinformaticians in Nigeria by leveraging open science principles to address the current expertise deficit in the field. We plan to establish a robust community through a combination of training workshops, mentorship programs, and the development of open-access resources. Key activities include organizing workshops to equip participants with essential bioinformatics and open science skills and knowledge, creating resources that will help the community adapt open science tenets to their work and launching an open training and mentorship program to connect enthusiast with experienced with professionals. By fostering a culture of openness, we aim to enhance the quality and reproducibility of scientific research in Nigeria, encouraging collaboration and continuous learning. This initiative will create a sustainable ecosystem of professionals capable of driving innovation and contributing to global scientific advancements, ultimately bridging the expertise gap and promoting a more inclusive scientific community.

Developing a genetic information management system towards precision medicine

By: Zedias Chikwambi, Pageneck Chikondowa, Mahougnon Marie Madeleine Hidjo, Catherine Jonhera, Nyasha Lorraine Mapira

Mentored by: Manuel Lera Ramirez

Keywords: Genetics, Information management

Without such a tool, implementation of precision medicine is difficult if not impossible. Existing genetic information management tools are subscribed for, which pushes the genotyping service way up. Guidelines in common use were developed mostly using genetic and phenotypic information from other population that are not of African ancestry, making the generalisation of the recommendations difficult and less useful. The proposed project aims to address these shortcomings by taping into the wealth of genetic information and lessons learnt on African populations ignorer to make the solution relevant to Africa, and Zimbabwe in particular.

CABANAnet (Capacity Building for Bioinformatics in Latin America)

By: Rebeca Campos Sanchez, Maria Fernanda Ribeiro Dias, Alessandra Serain, Nilson Coimbra

Mentored by: Alexander Martinez Mendez

Keywords: Training, eLearning

The CABANA project is a program that strengthens individual, institutional, and regional capacity through six main activities: secondments (long-term visits and exchanges), train-the-trainer activities, training workshops, eLearning, research projects, and knowledge exchange meetings (KEM).

TidyScreen: managing large drug screening campaigns

By: Alfredo Quevedo

Mentored by: Gemma Turon Rodrigo

Keywords: Drug screening, Python

Research efforts oriented towards the virtual screening of drugs encompasses the work with huge chemical libraries covering a massive chemical space. The nature of this chemical space is mainly governed by the biophysical features of the therapeutic target in study, as well as the synthetic protocols envisioned to obtain new drug candidates. In this way, a plethora of Python packages have been developed in order to solve different problems related to the associated screening workflows. However most of the available solutions as Python packages for the work with chemistry problems functions in an isolated manner, and generates a vast amount of information in heterogeneous ways. In this context, developing systematic and organized approaches to perform such scientific explorations, involving the development of reproducible and adequately organized data processing and storing workflows within structured query databases maximizes the success rate of drug discovery research campaigns. This project is oriented towards generating this kind of solutions, allowing both new and experienced researchers to perform adequately designed and reproducible virtual drug screening campaigns.

Building a Collaborative Network to Advance Bioimaging in Latin America

By: Andrés Olivera

Mentored by: Esther Plomp

Keywords: Bioimaging

LABI is a regional network that promotes bioimaging in Latin America. We are dedicated to building capacity and fostering collaboration in the region. Through training programs, professional development and opening access to infrastructure, we seek to democratize knowledge and technology in bioimaging. Our goal is to foster scientific research and technological innovation, promoting quality standards and best practices in the use of imaging technologies. In addition, we facilitate the exchange of knowledge and experiences among researchers and technicians from the region and the world. We work in close collaboration with academic institutions, research centers, companies and international organizations to advance the field of bioimaging and contribute to scientific and technological progress in Latin America.

Standards in bioinformatic pipelines

By: Yalbi I Balderas-Martinez

Mentored by: Hans-Rudolf Hotz

Keywords: Reproducibility, Bioinformatic pipelines

Sometimes it is dificult to reproduce a scientific paper, we want to set a mínimo of rules to make reproducible the bioinformatic pipelines, that all papers should contain. How we must set up the project in GitHub, in English and Spanish version

MolerHealth

By: Monsurat Onabajo, Manifest Chakalov, Bilikis Fadeyi

Mentored by: Mallory Freeberg

Keywords: Electronic health records, Healthcare system

The Molerhealth project aims to revolutionize healthcare in Nigeria by developing an open-source electronic health records (EHR) application. This initiative addresses the critical issue of disease misdiagnosis by enhancing information sharing and collaboration among healthcare providers, leading to better patient outcomes and a more efficient healthcare system. Molerhealth offers a secure, user-friendly platform for individuals to access, update, and share their comprehensive health records, regardless of location or healthcare provider. This EHR system ensures seamless continuity of care by making patients’ medical history, test results, medications, allergies, and treatment plans readily available to healthcare professionals. Leveraging technology, Molerhealth will significantly reduce misdiagnoses in Nigeria. Doctors will access complete, up-to-date patient profiles, enabling accurate diagnoses, appropriate treatments, and timely specialist referrals.

Deciphering the Role of Phosphatidylethanolamine Transferase (PEMT) in Glioblastoma MULTIFORME CELL INVASION, PROLIFERATION AND AGGRESSION

By: Susan Njuki, Ahmed Abdille, Brevin Ochieng Olunga, George Odongo

Mentored by: Caleb Kibet

Keywords: Cancer

Introduction: Cancer cells reorganize their metabolism to sustain cell growth and adapt to unfavorable microenvironments. Kang and colleagues (2018) state that metabolic reprogramming in cancer cells result in diverse metabolic dependent perturbations that may be targeted for cancer treatment. Generally, for instance, lipid metabolism powers the rapid growth, migration, invasion, and metastasis of tumor cells (Cheng et al., 2016). Nonetheless, little is known about the functions of PEMT in tumor aggression, especially in GBM. Therefore, we hypothesize that PEMT contributes greatly to increased GBM invasion, proliferation and aggression capacities. Methods: To investigate the role of PEMT in GBM aggressiveness, we cloned the PEMT gene into U251 cell lines to overexpress the gene shRNA-mediated knockdown to silence the gene. Overexpression (OE) and knockdown (KD) were validated by microscopy, WB and RT-PCR. We conducted functional assays including, cell proliferation and cell viability. Subsequently, we confirmed epithelial-mesenchymal transition (EMT) driving markers by RT-PCR and WB.

Enhancing Openness in the Prediction of Bacterial Pathogens in Yellowing Disease of Coastal Kenyan Coconuts through Machine Learning

By: Adolf Oyesigye Mukama, Fatma Mohamed Omar

Mentored by: Sebastian Ayala Ruano

Keywords: Bacterial pathogens, Open-access database

The project focuses on leveraging machine learning to predict bacterial pathogens responsible for the yellowing disease in coastal Kenyan coconuts. By developing an open-source platform, we aim to foster collaboration, transparency, and community engagement in agricultural research. The project involves creating an open-access database of bacterial pathogens and coconut plant health data, which researchers and agricultural professionals can use and contribute to. We will develop machine learning algorithms for pathogen identification and disease prediction, providing valuable tools for proactive disease management. A user-friendly web-based platform will ensure easy access to data and tools, catering to users with varying technical expertise. This project enhances research capabilities, empowers local communities with predictive models, promotes openness and collaboration, and builds capacity through training and educational resources. The goal is to create a collaborative environment where knowledge is share

Participants

The GitHub avatar of

Adolf Oyesigye Mukama

Pronouns: He/Him
@AdolfOyesigye

Expertise:
Bioinformatics

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Ahmed Abdille

Pronouns: GSU
@Ahmed A. Abdille

Expertise:
Cancer, Amps, Drug discovery
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Alessandra Serain

@aleserain

Expertise:
Precision medicine, Genomics, Oncology
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Alfredo Quevedo

@alfrequevedo

Expertise:
Medicinal chemistry, Computational chemistry

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Alyaa Elbadawi

Expertise:
Genetics, Bioinformatics, Data curation, Microbiome, Cancer genomics

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Andrés Olivera

Pronouns: He, Him
@A_Olivera_

Expertise:
"science management" "public policy" "chronobiology"

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Ayomide Akinlotan

Pronouns: He/his
@aymd23

Medical Laboratory Science of Lead City University

Expertise:
Bioinformatics

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Bilikis Fadeyi

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Brevin Ochieng Olunga

@BrevinOchieng

Expertise:
Virology; research methodology

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Catherine Jonhera

Pronouns: She/her

Expertise:
Pharmacogenomics;bioinfomatics
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Emmanuel Adamolekun

Pronouns: He/Him
@EAdamolekun

Helix Biogen Institute

Expertise:
Bioinformatics, Genomics, Community building

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Faisal Fadlelmola

Pronouns: He/Him
@Faisalfadl

Expertise:
Genetics, Genomics, Bioinformatics, Biomedical data science

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Fatma Mohamed Omar

Pronouns: Miss
@omar_fatma99

Expertise:
Molecular biology; genome analysis; metagenomics; microbiome analysis

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George Odongo

Pronouns: Mr
@GeorgeLugonzo

Expertise:
Microbiology

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Maria Fernanda Ribeiro Dias

Expertise:
Bioinformatics; machine learning; structural biology

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Mahougnon Marie Madeleine Hidjo

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Monsurat Onabajo

Pronouns: she/her
@onabajo3

Expertise:
Healthcare; data science; research

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Manifest Chakalov

Pronouns: he, him, his
@mq_nifest

Expertise:
Ai, Llm, Software development

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Nihad Alsayed

Expertise:
Genetics, Bioinformatics, Data curation, Microbiome, Cancer genomics

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Nilson Coimbra

Expertise:
Comparative genomics, Antibiotics resistente, Computational biology
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Nyasha Lorraine Mapira

Pronouns: She/Her

Expertise:
Rare genetic disorders, Pharmacogenetics , R programming, Linux, Ngs data analysis

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Pageneck Chikondowa

@Pageneck Chikondowa

Expertise:
Genomics, Bioinformatics

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Rebeca Campos Sanchez

Pronouns: she/her

Expertise:
Bioinformatics, Genomics

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Seun Olufemi

Pronouns: He/him
@seunolufemi9

Role in OLS: Resident Fellow

Expertise:
Bioinformatics/ open science/ community building

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Susan Njuki

Pronouns: she/her
@Njuki_Sue

Expertise:
Metabolomics , Cancer research

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Yalbi I Balderas-Martinez

Pronouns: She/her

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Zedias Chikwambi

Pronouns: he/his/him

Expertise:
Biotechnology, Computational biology

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